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Meet Your Interstitium – a Newfound “Organ”

~From Scientific American is part of Springer Nature, which owns or has commercial relations with thousands of scientific publications

Listen to the Story of the Interstitium

What Is the Interstitium?

From: WebMD Medically Reviewed by Jennifer Robinson, MD on August 17, 2022 Written by John Donovan
Experts have long thought parts of the body (like skin, veins and arteries, and the lining around muscles) contain walls of collagen, the main component of connective tissue. Instead, as the new study points out, those “walls” aren’t walls at all. Instead, they’re spaces filled with fluid that are simply supported by collagen. Those spaces are the interstitium.

This new “organ” — it’s not officially recognized as one yet — acts as a kind of shock absorber for the body, the researchers say. The scientists found interstitium in tissue from the lungs and aorta, the digestive tract and bladder, in the skin, and in many other spots — all places that expand and contract, where a “shock absorber” is important to protect tissue.

From: Structure and Distribution of an Unrecognized Interstitium in Human Tissues
With all that’s known about human anatomy, you wouldn’t expect doctors to discover a new body part in this day and age. But now, researchers say they’ve done just that: They’ve found a network of fluid-filled spaces in tissue that hadn’t been seen before. These fluid-filled spaces were discovered in connective tissues all over the body, including below the skin’s surface; lining the digestive tract, lungs and urinary systems; and surrounding muscles, according to a new study detailing the findings, published today (March 27) in the journal Scientific Reports.

Interstitium (from WikiPedia)

In anatomy, the interstitium is a contiguous fluid-filled space existing between a structural barrier, such as a cell membrane or the skin, and internal structures, such as organs, including muscles and the circulatory system. The fluid in this space is called interstitial fluid, comprises water and solutes, and drains into the lymph system. The interstitial compartment is composed of connective and supporting tissues within the body – called the extracellular matrix – that are situated outside the blood and lymphatic vessels and the parenchyma of organs. The role of the interstitium in solute concentration, protein transport and hydrostatic pressure impacts human pathology and physiological responses such as edema, inflammation and shock.

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1. Orion Magazine – Interstitium Invisible Landscapes
2. Interstitium: Scientists say they’ve discovered a new human organ
3. The National Library of Medicine – The Interstitium